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<<Penza State University>>

Medical Institute

Course Paper

In History

<<George Richard minot(1885-1950) – nobel prize for his study of anemia >>

Student :vamja deep b.

Group: 19ll4A

Instructor: Dr. Gavrilova Tatiana Victorovna

Content

1. George Richard minot

2. Early life

3. Education

4. Career

5. Contribution for medicine

(Picture no 1:George ricard minot)

1. George Richard minot:

· George Richards Minot (December 2, 1885 – February 25, 1950) was an American medical researcher who shared the 1934 Nobel Prize with George Hoyt Whipple and William P. Murphy for their pioneering work on pernicious anemia.

2. Early life:

· George Richards Minot was born in Boston, Massachusetts to James Jackson Minot (1853–1938) and Elizabeth Whitney. He was namesake of his great-great-grandfather George Richards Minot (1758–1802). His father was a physician; his father's cousin was anatomist Charles Sedgwick Minot (1852–1914); one of his great-grandfathers was James Jackson (1777–1867), co-founder of Massachusetts General Hospital. He developed interest, first, in the natural sciences, and then, in medicine.

3. Education:

· Minot obtained his B.A. from Harvard College in 1908, where he was elected to The Owl Club, and obtained his M.D. degree in 1912 from the Harvard Medical School. Between 1913 and 1915, he worked in the William Henry Howell's lab at the Johns Hopkins Medical School in Baltimore, MD., studying blood thinning proteins, such as antithrombin. In 1915, he secured a junior position on the medical staff of the Massachusetts General Hospital, where he started research on blood anemia. During the first world war, he served as a surgeon in for the US Army. As part of those duties, he worked with Alice Hamilton to understand what was causing workers at a munitions plant in New Jersey to become ill. They eventually discovered that skin contact with TNT led to the sicknesses.

4. Career:

· in 1917, he came to Collis P. Huntington Memorial Hospital in Boston; he became chief of medical services in 1923, and was appointed physician-in-chief in 1934. In addition, Minot became professor of medicine at the Harvard University, and was appointed director of the Thorndik Memorial Laboratory at Boston City Hospital. He also worked in the Peter Bent Brigham Hospital as a staff member. He was a member of the Pernicious Anemia Committee at Harvard and served on the Anti-Anemia Preparation Advisory Board of the U.S. Pharmacopoeia.

· In 1930, Minot was awarded the Cameron Prize for Therapeutics of the University of Edinburgh with William P. Murphy. Minot shared the 1934 Nobel Prize in Physiology or Medicine with William P. Murphy and George H. Whipple given for their work on the treatment of blood anemia. They all discovered an effective treatment for pernicious anemia, which was a terminal disease at the time, with liver concentrate high in vitamin B12, later identified as the critical compound in the treatment.

· Minot was diagnosed with diabetes mellitus in 1921 at the age of 35, by Dr Elliott P. Joslin, a fellow professor at Harvard Medical School and one of the leading diabetes doctors of his time. Diabetes was a fatal disease at the time. Joslin kept him alive the only way he knew, by restricting food. Minot was 6 feet one inches tall and only weighed 135 pounds. Joslin put him on a diet of only 530 calories per day. Minot, like most every diabetes patient, at the time, would probably die within a year.

· However, insulin was discovered at about the same time Minot was diagnosed. Insulin became widely available about a year later. Dr. William Castle observed that Frederick Banting's and Charles Best's discovery of insulin in 1921, not only transformed diabetes treatment, but also, by keeping Minot alive, contributed towards the discovery of a cure for pernicious anemia.

· Minot began developing complications associated with diabetes in 1940, and suffered a serious stroke in 1947, which partially paralyzed him. He died in Brookline, Massachusetts on February 25, 1950. He was a Unitarian. His home in Brookline, Massachusetts, was designated a National Historic Landmark in recognition for his work.

· Minot and his wife Marian Linzee Minot (Weld) (1890-1979), whom he married in 1915, had two daughters and a son.

(Picture no 2: Dr.george r miont with anemia)

5. Contribution for medicine:

· Minot early became, when he was a medical student, interested in the disorders of the blood with which his name is associated and he published during his life many papers on this and other subjects. Arthritis, cancer, dietary deficiencies, the part played by diet (vitamin B deficiency) in the production of so-called alcoholic polyneuritis and the social aspects of disease were among the subjects of his papers. Further he studied the coagulation of the blood, blood transfusion, the blood platelets and the reticulocytes as well as certain blood disorders, and he described an atypical familial haemorrhagic condition associated with prolonged anaemia. He also studied the condition of the blood in certain cases of industrial poisoning.

· Among his other interests were leucaemia, disorders of the lymphatic tissues and polycythaemia, but his most important contributions to knowledge were made in his studies of anaemia. His name will always be associated with the therapy of pernicious anaemia, in which he first became interested in 1914, but it was not until later that he, like William P. Murphy, became impressed by the work of George Hoyt Whipple on the treatment of experimental forms of anaemia in dogs, and in 1926 he and Murphy described the effective treatment of pernicious anaemia by means of liver. For this work he and Murphy and Whipple were awarded, in 1934, the Nobel Prize for Physiology or Medicine. Subsequently, Minot, in collaboration with Edwin J. Cohn, extended this work by showing the efficacy of certain fractions of liver substance and he demonstrated the value of reticulocyte reactions in the evaluation of therapeutic procedures. He also added to knowledge of gastro-intestinal functions and of iron therapy for anaemia, and to knowledge of other aspects of this group of diseases.

· Minot was member or fellow of numerous medical and allied organizations in his own country and abroad, and served as Editor of several medical publications. Among the many honours and distinctions he received, may be mentioned: the Cameron Prize in Practical Therapeutics of the University of Edinburgh, in 1930 (jointly with W. P. Murphy), the Popular Science Monthly Gold Medal and Annual Award for 1930 (jointly with G. H. Whipple), and the John Scott Medal of the City of Philadelphia.

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