But when the microglia regenerated, this led to astounding results: researchers ran the same memory tests on the rats, and they performed 25-50% better than normal rats.

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Importantly, the regenerated microglia were a different shape -- similar to the “activated” shape that these cells have when dealing with inflammation.

“We are still exploring what makes these cells different when they repopulate the brain, but their shape tells us they may be more active than usual, potentially making the neurons more effective to encourage better memory,” Spencer, an NHMRC Career Development Fellow at RMIT, said.

“The effect doesn’t last. As the microglia go back to their usual shape, memory

performance also goes back to normal.

SPG^^:Idea of immune cells in brain is interesting, or specifically brain’s immune system. Also microglia in the brain being activated and that increasing memory.

Next Steps:

Activating microglia (what happens, memory, what they are, etc) – does this support short-term memory improvements?

Nutrients that help activate microglia. https://www.sciencedaily.com/releases/2019/03/190314075747.htm

Date: March 14, 2019 Source: Rutgers University

Summary:

How much vitamin D can boost memory, learning and decision-making in older adults, and how much is too much? A unique study found that overweight and obese older women who took more than three times the recommended daily dose of vitamin D showed improvements in memory and learning -- but also had slower reaction times. The researchers hypothesize that slower reaction times may increase the risk of falling among older people.

^^ SPG Note:Vitamin D helps support neural stem cells. So interesting that it also supports memory. Makes sense.

The researchers, whose work is in the Journals of Gerontology: Series A, used computers to assess the impact of vitamin D on cognitive function. The researchers evaluated three groups of women between 50 and 70 years old in a randomized controlled trial.

One group took the recommended daily dose of 600 international units (IU), equivalent to 15 micrograms, of vitamin D each day for a year. Another group took 2,000 IU per day and the third took 4,000. All women participated in lifestyle counseling and were encouraged to lose a modest amount of weight.

The researchers found that memory and learning improved in the group that took 2,000 IU per day, but not in the group that took the higher dosage. Meanwhile, the women’s reaction time showed a trend to be slower at 2,000 IU daily and was significantly slower at the higher dosage.

Study referenced: https://academic.oup.com/biomedgerontology/advance- article-abstract/doi/10.1093/gerona/glz041/5320009?redirectedFrom=fulltext

https://www.sciencedaily.com/releases/2020/01/200113153330.htm

^^ interesting, good paradoxical question, but a little complicated + talking about genetic factors.

https://www.sciencedaily.com/releases/2020/03/200305203531.htm

^^ some interesting stuff about how memory works.

https://www.sciencedaily.com/releases/2018/01/180129134354.htm

^^ just interesting because another thing about electrical stimulation, similar to Stanford study I viewed earlier. This one from the Mayo Clinic.

https://www.sciencedaily.com/releases/2018/05/180514132450.htm Date: May 14, 2018

Source: Society for Neuroscience

Summary:

Memories can be transferred between organisms by extracting ribonucleic acid (RNA) from a trained animal and injecting it into an untrained animal, as demonstrated in a study of sea snails.

https://www.sciencedaily.com/releases/2020/04/200402144504.htm Date: April 2, 2020

Source: King’s College London

Summary:

Researchers have shown that how we respond to changes in nutrients at a molecular level plays an important role in the aging process, and this is directed by some key genetic mechanisms.

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