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Brain/Memory

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Supplement or Nutritional Guide.

https://www.sciencedaily.com/releases/2020/04/200402144504.htm Date: April 2, 2020

Source: King’s College London

Summary:

Researchers have shown that how we respond to changes in nutrients at a molecular level plays an important role in the aging process, and this is directed by some key genetic mechanisms.

Published in Communications Biology, the study explored the molecular interactions that occur in our response to varying levels of nutrients, otherwise known as nutrient-sensing pathways, as we grow older.

Using a combination of laboratory-based techniques and analysis of data on people’s memory, diet and level of physical exercise, researchers identified a number of genes that are active in nutrient-sensing pathways and demonstrated these genes also show associations to performance on memory tasks in data from over 2000 individuals. The study identified that the genes ABTB1 and GRB10 were both influential in nutrient sensing pathways and showed association to memory.

Previous studies have indicated that neural stem cells (NSCs) in the hippocampal part of the brain play an important role in the decline of our thought process and memory over time. NSCs are cells that keep dividing as long as they are alive and either make more NSCs or cells that have a specialist function in the brain. The maintenance of these NSCs is important in memory and is affected by environmental factors such as diet and exercise, potentially explaining some of the variation in how ageing affects different people.

^^ SPG NOTE:Could be looking for nutrients that support neural stem cells.

Next Steps:

Get a little more information on neural stem cells

Look at nutrients/ingredients that have been shown to support them. https://www.sciencedaily.com/releases/2020/02/200214134725.htm

Date: February 14, 2020

Source: DZNE - German Center for Neurodegenerative Diseases

Summary:

Memory performance and other cognitive abilities benefit from a good blood supply to the brain. This applies in particular to people affected by a condition known as ‘sporadic cerebral small vessel disease’. Researchers suggest that blood perfusion of the so-called hippocampus could play a key role in age- and disease-related memory problems.

Inside the human brain there is a small structure, just a few cubic centimeters in size, which is called the “hippocampus” because its shape resembles a seahorse. Strictly speaking, the hippocampus exists twice: once in each brain hemisphere. It is considered the control center of memory.

A team of scientists headed by Prof. Stefanie Schreiber and Prof. EmrahDuezel, both affiliated to the DZNE and the University Medicine Magdeburg, investigated this question. The researchers used high-resolution magnetic resonance imaging (MRI) to examine the blood supply to the hippocampus of 47 women and men aged 45 to 89 years. The study participants also underwent a neuropsychological test battery, which assessed, in particular, memory performance, speech comprehension and the ability to concentrate.

“Our study shows a clear link between blood supply to the hippocampus and cognitive performance,” Schreiber summarized the results. “This suggests that brain blood flow might play a key role in the declining of memory performance, whether caused by age or disease.”

SPG:Make up a term like Cognitive Circulation. Mechanism would be basically something like: increased blood flow to the brain, aka cognitive circulation, supports better memory.

Next Steps:

Prove that’s true (that increased blood flow improves memory) and find nutrients that increase blood flow to the brain.

https://www.sciencedaily.com/releases/2019/08/190823140731.htm Date: August 23, 2019

Source: Salk Institute

Summary:

Researchers have discovered that star-shaped cells called astrocytes help the brain establish long-lasting memories. The work could inform therapies for disorders in which long-term memory is impaired, such as traumatic brain injury or dementia.

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