Antibacterial chemotherapeutic

↑

⇐ ПредыдущаяСтр 4 из 5Следующая ⇒

ANTIBACTERIAL CHEMOTHERAPEUTIC

AGENTS OF DIFFERENT CHEMICAL GROUPS

1. Determine the group of drugs:ciprofloxacin, norfloxacin, sulfadimidin, levofloxacin, furazolidone, co-trimoxazole, furazidin, phthalylsulfathiazole, nalidixic acid, sulfacetamide, nitroxoline, chinoxidine, linezolid, moxifloxacin.

1. Sulfonamides; B. Quinolones; C. 8-oxyquinolines; D. Nitrofurans ; D. Quinoxalines; E. Oxazolidinones.

2. Compare drugs and fill in the table

Comparison options

Sulfonamides

Nitrofurans

F-Quinolones

The type of activity

       bacteriostatic

       bactericidal

Spectrum of action

Gram-positive bacteria

Gram-negative bacteria

Pseudomonas aeruginosa

Chlamidia, mycoplasma

malarial Plasmodium

Giardia

Side effects

violation of hematopoiesis

crystalluria

violation of cartilaginous tissue formation

dyspeptic disorders

photodermatosises

Contraindications

Pregnancy

Children's age

3. Indicate, using the table, the possible mechanism of action of sulfonamides and trimethoprim and answer questions:

Characteristic

Sulfonamides

Trimethoprim

Competitive antagonism with para-aminobenzoic acid

Blockade of the enzyme

Dihydropteroate synthase

Dihydrofolate reductase

Violation of synthesis of

Dihydrofolic acid

Tetrahydrofolic acid

Violation of the synthesis of purines, DNA, RNA

4. Answer the questions:

A. What is the type of action of combining sulfonamides with trimethoprim?

B. Why do not sulfanilamidy disrupt protein synthesis in human cells?

C. Why are they not active in conditions of a purulent wound?

5. Specify the mechanism of action of quinolones:

- activity of DNA gyrase and topoisomerase 4 (↑↓),

- the synthesis of DNA and fold it into the chromosome (↑↓),

- morphological changes in the cytoplasm and cell wall (reversible / irreversible),

- formation of endotoxins (↑↓),

- type of action (bacteriostatic / bactericidal).

6. Finish the expressions by selecting the correct answer about fluoroquinolones:

- the spectrum of action of fluoroquinolones is (wide / narrow)

- they are (low-/ high-toxic) for man

- secondary resistance develops (quickly / slowly)

- orally bioavailability is (high / low)

- they penetrate into the tissue (well / badly)

- they penetrate through the BBB (Yes / no)

- use for the treatment of tuberculosis is (possible / impossible)

7. Determine drugs (nalidixic acid, ciprofloxacin, levofloxacin, moxifloxacin):

Познавательные статьи:



Техника прыжка в длину с разбега

Тактические действия в защите

История Олимпийских игр

История развития права интеллектуальной собственности